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Caffeine intake, tolerance, and withdrawal in women: a population-based twin study. Am J Psychiatry. A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins. Drug Alcohol Depend.
Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. Arch Gen Psychiatry.
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Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. J Clin Pharmacol. Biomed Chromatogr. Xanthine oxidase activity is influenced by environmental factors in Ethiopians. A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test. Human liver xanthine oxidase: nature and extent of individual variation. Caffeine metabolism in a healthy Spanish population: N-acetylator phenotype and oxidation pathways. Pharmacokinetics of caffeine in plasma and saliva, and the influence of caffeine abstinence on CYP1A2 metrics.
J Pharm Pharmacol. Effects of exercise and thermal stress on caffeine pharmacokinetics in men and eumenorrheic women. Cytochrome P IA2 activity in man measured by caffeine metabolism: effect of smoking, broccoli and exercise. Adv Exp Med Biol. A distribution study of CYP1A2 phenotypes among smokers and non-smokers in a cohort of healthy Caucasian volunteers.
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Effect of smoking on caffeine clearance. Variability of cytochrome P 1A2 activity over time in young and elderly healthy volunteers. CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine. The pharmacology of caffeine. Prog Drug Res. PLoS Biol. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity.
PLoS One. Caffeine extends yeast lifespan by targeting TORC1.
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Mol Microbiol. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. EMBO J. Cell Cycle. Regulation of longevity and stress resistance by Sch9 in yeast. Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase. Computational study of the binding modes of caffeine to the adenosine A2A receptor.
J Phys Chem B. Caffeine and exercise.
Curr Sports Med Rep. Methylxanthines and sleep. Handb Exp Pharmacol. The role of adenosine in the regulation of sleep. Curr Top Med Chem. Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain.
Front Biosci. J Nucl Med. Sleep-wake and eeg effects following adenosine a1 agonism and antagonism: similarities and interactions with sleep-wake and eeg effects following a serotonin reuptake inhibitor in rats. Sleep Res Online. Intrinsic activity at adenosine A1 receptors: partial and inverse agonism.
Curr Pharm Des. Nomenclature and classification of purinoceptors. Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol. Adenosine A 1 and A 2A receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal. J Neurosci. Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice. Physiol Behav. Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain. Cell Mol Neurobiol. Role of adenosine receptors in caffeine tolerance.
J Pharmacol Exp Ther. Caffeine alters A2A adenosine receptors and their function in human platelets. Caffeine alters plasma adenosine levels. Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats. Pak J Pharm Sci. Effect of caffeine on the levels of brain serotonin and catecholamine in the genetically obese mice.
Effects of adenosine receptor subtypes on hippocampal extracellular serotonin level and serotonin reuptake activity. J Neurochem. The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. Analgesic effect of caffeine and clomipramine: a possible interaction between adenosine and serotonin systems. Acta Pharm. Hippocampal noradrenaline release in awake, freely moving rats is regulated by alpha-2 adrenoceptors but not by adenosine receptors.
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Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. Chronic effects of xanthines on levels of central receptors in mice. Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats. Br J Nutr. Acute and habitual caffeine ingestion and metabolic responses to steady-state exercise. Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens.
Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation. Lack of NMDA receptor involvement in caffeine-induced locomotor stimulation and tolerance in rats. Differential effects of caffeine on dopamine and acetylcholine transmission in brain areas of drug-naive and caffeine-pretreated rats. Caffeine enhances acetylcholine release in the hippocampus in vivo by a selective interaction with adenosine A1 receptors.
Chronic caffeine treatment reduces caffeine but not adenosine effects on cortical acetylcholine release.
Br J Pharmacol. Depletion of catecholamines in the brain of rats differentially affects stimulation of locomotor activity by caffeine, D-amphetamine, and methylphenidate. D1 and D2 dopamine receptor antagonists block caffeine-induced stimulation of locomotor activity in rats.